Iron Overload in Transfusion-Dependent Indonesian Thalassemic Patients

Thalassemia is a genetic disease caused by disruption of globin chain synthesis leading to severe anemia and thus regular blood transfusion necessary. However, there have been known transfusions-related consequences, including iron overload multi-organ damage. The aims this study were evaluate liver cardiac function in youth adult transfusion-dependent Indonesian thalassemic patients assess its correlation with serum ferritin levels, as well T2 ∗ magnetic resonance imaging (MRI). Transfusion-dependent (TDT) outpatients (n = 66; mean age, 21.5 ± 7.2 years) carried out for the complete assessment consisting test enzyme ferritin, followed electrocardiography (ECG) echocardiography. Subjects also divided levels into three groups: < 2500 ng/mL, 2500–5000 >5000 ng/mL. Additionally, subgroup analysis T2∗ MRI was conducted. In terms age first transfusion, subjects ng/mL youngest among others. alanine aminotransferase (ALT) group significantly higher than those <2500 TDT whose had lower tricuspid annular plane systolic excursion (TAPSE) when compared who Similarly, TAPSE moderate siderosis based on without siderosis. There significant, but only between MRI. Based these findings, it important routinely monitor accumulation-related complications, damage patients.